Laminin beta 1 anticorps (AA 31-270)

N° du produit ABIN966474

Cet anticorps anti-Laminin beta 1 est un anticorps Souris Monoclonal détectant Laminin beta 1 dans WB, IHC et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour Laminin beta 1 anticorps (AA 31-270) (ABIN966474)

Antigène: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Laminin beta 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 2D9G5

Détail du produit anti-Laminin beta 1 anticorps

Épitope: AA 31-270

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-Laminin beta 1 (ABIN966474)

Virtanen, Korhonen, Petäjäniemi, Karhunen, Thornell, Sorokin, Konttinen: "Laminin isoforms in fetal and adult human adrenal cortex." dans: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 10, pp. 4960-6, (2003) (PubMed).

Détails sur Laminin beta 1

Antigène: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Autre désignation: LAMB1

Sujet: LAMB1: laminin, beta 1. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Synonyms: CLM, MGC142015

ID gène: 3912